Twins, Birth Injuries, and Hypoxic-Ischemic Encephalopathy (HIE)

What are the risks of delivering twins?

What complications are associated with twin pregnancies?

risk factors for twins

Pregnancies involving twins and other multiples are considered high-risk. Although twins can often be delivered safely, they have a higher likelihood of experiencing  birth injuries and subsequent health complications. Twins are at higher risk of a neonatal brain injury called hypoxic-ischemic encephalopathy (HIE), which occurs when there is insufficient oxygenated blood traveling to the baby’s brain during or near the time of birth.

HIE can cause lifelong problems such as cerebral palsyseizure disorders, and developmental delays. In order to prevent HIE and other birth injuries, twins must be closely monitored throughout pregnancy and during labor and delivery.  Women expecting twins are often referred to maternal-fetal specialists (MFMs) for specialized care.

What is hypoxic-ischemic encephalopathy (HIE)?

Hypoxic-ischemic encephalopathy (HIE) is a brain injury caused by insufficient oxygenated blood flow to the baby’s brain (“birth asphyxia”). Problems with the placenta, uterus (womb), and umbilical cord are common causes of birth asphyxia and HIE. Premature babies are more susceptible to HIE and related forms of brain damage (such as periventricular leukomalacia) because their organs are underdeveloped and fragile.

Medical professionals should take this into account when managing twin pregnancies, as twins are more likely to be born prematurely.

Long term effects

Hypoxic-ischemic encephalopathy often evolves into permanent brain damage. HIE can cause the following lifelong conditions (1, 2):

What complications are associated with twin pregnancies?

Twin pregnancies are associated with numerous complications that can cause HIE, including:

  • Intrauterine growth restriction (IUGR)/Fetal growth restriction (FGR): The terms IUGR and FGR describe a condition in which an unborn baby’s growth is abnormally slow. Often, this is due to problems with the uterus or placenta (uteroplacental insufficiency). Twins and multiples are at increased risk of IUGR; one major reason is that the babies may be competing for nutrients from the placenta (3). Sometimes, one twin may be affected by selective IUGR due to unequal placental sharing (i.e. one baby gets more oxygen and nutrients than the other) (4). Babies with IUGR typically require early delivery in order to minimize the risk of HIE and other birth injuries (5).
  • Preeclampsia: Preeclampsia occurs in the latter half of pregnancy, and is characterized by the onset of high blood pressure and either protein in the urine or end-organ dysfunction. Preeclampsia can cause pregnant women to experience eclampsia (maternal seizures) and other life-threatening complications. It is also dangerous for the baby because it often results in decreased blood flow in the placenta, and increases the risk of placental abruption and premature delivery. All of these issues can lead to HIE (6).
  • Umbilical cord problems – intertwin cord entanglement: When twins’ cords become entangled, cord compression can occur, which restricts the blood flow going to the babies. Whenever blood flow is restricted, babies are at an increased risk of birth injuries like HIE (7).
  • Twin to twin transfusion syndrome (TTTS) in monochorionic (identical) twins: If the blood vessels of the two babies are abnormally connected, and one baby gets more blood flow than the other from the shared placenta, TTTS may occur. Treatments may include amniocentesis to drain excess fluid or laser surgery to seal off the connection between the blood vessels. Without prompt treatment, HIE and other birth injuries are possible. In severe cases, one or both babies may die (8, 9).
  • Death of one twin: If one twin dies, the surviving twin may be at risk of IUGR, preterm labor, preeclampsia, hypotension, and other problems that can lead to HIE (10).
  • Preterm delivery/premature birth: This is one of the most serious complications of a twin pregnancy. Twins born prematurely are at an increased risk of HIE and numerous other problems (e.g. brain bleedsinfections, and respiratory distress syndrome) due to the immaturity of their organs (11).

Video Transcript


MR. REITER: When someone is pregnant with twins they are–it’s high risk. So there are a lot of things that can go wrong with twins. One of the things that can go wrong is the babies can be delivered prematurely. And when a baby is delivered prematurely they can suffer brain damage or injury just due to the fact that they are premature. So there are ways to avoid being delivered prematurely and there are things that you can look to.

Many times, I’ve found cases where there was an infection that wasn’t treated appropriately or the mom had needed a cervical cerclage, which is a little stitch that’s placed in the cervix to hold the baby in. We look at things like that to see whether something could have been done to prevent the preterm delivery. Other things that can happen with twins occur in labor where they’re not monitored correctly and the baby suffered lack of oxygen to the brain. Or one baby is delivered and the second baby isn’t delivered soon enough, then the second baby suffers from lack of oxygen to the brain. So there are all kinds of high risk problems that can occur with twins and we see many, many cases of twins.

We recently had a case of twins where the mother was in labor and they had the fetal monitor on but the problem with twins is a lot of times it’s very difficult to continue to monitor the babies. As the labor progressed, one of the babies was not doing well and they didn’t pick up on this. So when they finally delivered the twins one baby had suffered brain damage from lack of oxygen to the brain or asphyxia.

So the key here was that the nurses weren’t vigilant in making sure that both babies’ heartbeats were monitored. They didn’t pick up on the fact that one of the babies was not getting enough oxygen and they should have picked up on that had they been more careful and followed the safety rules. So we pursued that case. We were able to discover that one of the babies did not get enough oxygen from not being monitored correctly and we were able to help that family.

So, if you have twins and one or both of your babies are having problems, come to us for a free consultation. We’ve helped out many families with twins that babies have suffered birth injuries.

Prenatal care and prevention of birth injuries in twins

Ultrasound testing in twin pregnancies

It is very important that medical professionals do proper fetal monitoring to check on the health of unborn twins. First, it is important to use routine ultrasound monitoring for multiple purposes during the first and second trimesters:

  • To confirm the presence of a twin pregnancy.
  • To accurately estimate the twins’ gestational age. This is important in monitoring for IUGR/FGR and in timing planned early deliveries (when necessary).
  • To determine the type of twin pregnancy (e.g. whether the twins are sharing a chorion, amniotic sac, and/or placenta). This can help in assessing risk for complications such as TTTS and umbilical cord entanglement.
  • To assess the health of identical twins’ shared uteroplacental circulation and identify serious pregnancy complications like TTTS.
  • To assess fetal growth.

Ultrasounds during the first trimester can also detect abnormalities such as crown-rump length discordance (when one twin is bigger than the other; this is associated with TTTS).

Twin pregnancies typically involve more frequent prenatal testing than singleton pregnancies. This may include serial ultrasounds, nonstress tests (NSTs), amniotic fluid tests, and biophysical profiles (BPPs). If complications (such as IUGR) arise, testing will be performed even more frequently. Each twin must be accurately identified. Medical professionals should also document important features like the sites of placental implantation and the sites and types of placental cord insertion (12).

fetal ultrasound

Doppler studies during prenatal care for twins

More intensive fetal monitoring in the form of Doppler studies is needed if an ultrasound identifies growth discordance or IUGR, or if the mother has anemia (12). Doppler ultrasounds use sound waves to measure the amount and speed of blood flow through the blood vessels. They can be used to check the flow of blood in the umbilical cord and vessels of the uteroplacental circulation.

Early delivery of twins

Over half of twin pregnancies involve either spontaneously-occurring or medically-indicated premature birth (13). Even in uncomplicated twin pregnancies, slightly premature delivery may be advisable. In making decisions about timing of delivery, doctors should consider which of the following categories the twins fit into:

  • Dichorionic-diamniotic: These twins have their own chorions and amniotic sacs, and generally also have their own placentas. They can be fraternal or identical.
  • Monochorionic-diamniotic: These twins have their own amniotic sacs, but share a chorion and a placenta.They are identical twins.
  • Monochorionic-monoamniotic: These twins share a chorion, an amniotic sac, and a placenta. They are identical twins (13, 14).

Typically, there are greater risks associated with monochorionic twin pregnancies, and certain complications (such as twin-twin transfusion syndrome) are unique to monochorionic pregnancies. Therefore, these twins are generally delivered earlier than dichorionic twins (12, 13, 14). Exact recommendations vary, but the American College of Obstetrics and Gynecology (ACOG) suggests that dichorionic-monochorionic twins (in an otherwise uncomplicated pregnancy) be delivered between 34 weeks and 37 weeks + six days (13). Monochorionic twins may need to be delivered even earlier, and via cesarean section, because they are at high risk of umbilical cord entanglement and compression (16).

Benefits of a scheduled twin delivery

One of the advantages of a scheduled early delivery is having a care team and treatments ready to go if required. Twins may need medical intervention as soon as they are born. These interventions can include resuscitation, cardiovascular support, respiratory support, blood transfusions, and even surgery. In addition, twins at risk of premature birth can be given important medications (steroidsmagnesium sulfate) in-utero to help prevent birth injuries and brain damage.  However, these must be given shortly before birth to be effective (12). Infection in the baby is also a major risk of spontaneous preterm birth. Preventing premature rupture of the membranes by having a scheduled delivery can decrease babies’ risk of infections like meningitis and sepsis, which can cause permanent brain damage.

Indications for emergency delivery

If one or more of the babies isn’t getting enough oxygen and/or nutrients, delivery may need to occur earlier than initially planned. The following are just a few examples of possible indications for an emergent premature delivery:

If doctors recognize signs of fetal distress (such as an abnormal heart rate), emergency delivery will also often be necessary.

Should I have a scheduled c-section or labor induction for my twins?

Planned early delivery is almost always advisable to prevent HIE and other birth injuries in twin pregnancies. This planned delivery can occur either with a scheduled C-section or with a labor induction. Labor inductions can occur with:

  • Pitocin (synthetic oxytocin), which augments or induces labor
  • Misoprostol (Cytotec), which ripens and thins the cervix
  • Transcervical Foley catheter, which is a balloon used to help dilate the cervix
  • Amniotomy, wherein a medical professional artificially ruptures the membranes in order to start or increase contractions

Each procedure carries with it attendant risks and advantages (such as uterine hyperstimulation/tachysystoleuterine ruptureumbilical cord prolapse, and infection). Often, medical professionals recommend early scheduled C-sections for twin births, though the timing may vary depending on the mother and baby’s health profiles. Medical professionals should thoroughly explain the risks and benefits of all procedures and medications to mothers in order to obtain informed consent.

What to do if your twin(s) had birth injuries

If one or both of your twins had a birth injury, the first step is to seek appropriate medical care. Additionally, if you are concerned that a birth injury stemmed from an error that a medical professional made – whether it was during prenatal care, labor, or delivery – it may be helpful to ask the birth injury attorneys at ABC Law Centers: Birth Injury Lawyers (Reiter & Walsh, P.C.) to review your case.

Case review is 100% free and confidential. The money from a birth injury verdict or settlement can be used to secure your child’s future, provide them with therapy and medical equipment, and alleviate the costs of medical care and accessible housing that existing insurance and assistance programs won’t cover.


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