Gestational Diabetes

Gestational diabetes is one of the most common health issues that can occur during pregnancy. It occurs when the mother is first diagnosed with diabetes partway through the pregnancy. The key to minimizing the effects of gestational diabetes is diagnosing it early using an oral glucose tolerance test. If gestational diabetes is not diagnosed properly, it can lead to macrosomia in the baby (abnormally large fetal size), which puts the baby at risk for neonatal hypoglycemia, trauma, and other complications. It can also lead to jaundice, premature birth, birth asphyxia and reduced uteroplacental perfusion (RUPP), which harms both mother and child by reducing blood flow between baby and mother.


Gestational Diabetes and Birth Injury

During pregnancy, hormonal changes can make an expectant mother’s cells less responsive to insulin. When a person’s body needs more insulin, the pancreas secretes more. However, pregnant women often experience increased insulin demand during pregnancy, and, as a result, their pancreases cannot keep up with the demand. Ultimately, these pregnant women experience heightened blood glucose levels with resultant gestational diabetes.

Currently, the American College of Obstetricians and Gynecologists (ACOG) and the American Diabetes Association recommend screening all pregnant women for gestational diabetes. Additionally, ACOG states that women who develop pregnancy-related diabetes should be re-tested 6 to 12 weeks after delivering their babies.

However, according to a new study of one million patient records, only about two-thirds of pregnant women undergo screening tests for gestational diabetes. Among the 5% of women who tested positive for gestational diabetes, just 1 in 5 were screened again within 6 months of giving birth, explains Jon M. Nakamoto of Quest Diagnostics Nichols Institute in San Juan Capistrano, California.

The findings are particularly concerning, Nakamoto says, given that a recent large study, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) trial, found that even subtle defects in maternal glucose metabolism during pregnancy led to health problems for mother and baby.

Gestational Diabetes Linked to Birth Injury: High-Risk Pregnancy

Gestational diabetes places mothers in the high-risk category for pregnancy, as gestational diabetes poses an increased risk for complications during pregnancy and labor and delivery. With proper monitoring and care, however, the risks of high-risk pregnancies can be mitigated, resulting in a healthy baby.

Mothers who have a high-risk pregnancy are referred to maternal-fetal specialists and require more frequent prenatal testing. In addition, these mothers are often advised to have a scheduled, early delivery in order to minimize the risks associated with their specific high-risk conditions. Indeed, when continuation of a pregnancy is associated with increased risk of uterine rupture, premature rupture of the membranes (PROM), hemorrhage and other harmful conditions, early delivery is often indicated.

Gestational Diabetes Linked to Birth Injury: Premature Birth

In many cases, it is safest for babies of mothers with gestational diabetes to be delivered in a scheduled delivery prior to 40 weeks. If a mother’s diabetes is poorly controlled, delivery is recommended as early as week 34. Although premature birth does have associated risks, in the can of diabetes, the benefits of early delivery outweigh the risks. With proper postnatal care, babies born at 34+ weekly typically do well.

Gestational Diabetes Linked to Birth Injury: Macrosomia

Macrosomia and HIEMothers with diabetes often have high blood sugar levels, which are passed on to the baby through the placenta. This large amount of energy is put towards growth, but it can result in a baby being too large (macrosomic), which increases the baby’s risk of a traumatic birth. Babies with macrosomia are most safely delivered via C-section. If macrosomia goes undetected, this may result in a prolonged or arrested labor or in traumatic injury to the baby’s head or brain.

Gestational Diabetes Linked to Birth Injury: Neonatal Hypoglycemia

While in utero, babies are used to having a certain supply of glucose from the mother. Once they are born, they begin having to produce their own energy stores. While in utero, they produce larger quantities of insulin to process the existing larger supply of blood sugar – but when they are born, the amount of insulin they produce doesn’t drop as quickly as their glucose supply does. If they don’t take in enough energy as newborns, their blood sugars drop dangerously low. This is a problem, because blood sugar is the sole energy source for the brain. If low blood sugar (hypoglycemia) goes on, brain cells start to die, which can cause seizures and permanent brain damage. After birth, its very important to monitor the baby’s blood sugar, especially if their mother had diabetes, in order to prevent it from dipping too low.

Gestational Diabetes Linked to Birth Injury: Hypoxic-Ischemic Encephalopathy and Cerebral Palsy

Hypoxic-Ischemic Encephalopathy (HIE) can result from many different causes, but at its core, it is a brain injury caused by a lack of blood and oxygen flow to the brain. In babies impacted by diabetes, this can happen due to other diabetes- associated complications, like a prolonged labor or traumatic delivery due to macrosomia. If babies are macrosomic and there is trauma involved in the birth, this could collapse the blood vessels in the baby’s brain, leading to HIE. Medical practitioners are trained to recognize sentinel events and conditions that could potentially cause injury – and should be trained to avoid injury and provide care that is up to the ‘standards of care.’ If they do not provide proper care, the baby may suffer HIE and resultant cerebral palsy.

Gestational Diabetes Linked to Birth Injury: Neonatal Seizures

Neonatal seizures are one sign that a baby has neurological abnormalities, as marked by abnormal electrical discharges in the brain. Seizures are very common in the presence of hypoxic-ischemic encephalopathy (HIE), as well as in neonatal hypoglycemia. Neonatal hypoglycemia can cause brain cell damage, which in turn can cause seizures. It is very important that medical professionals bring seizures under control, because continuing seizures can make underlying brain damage worse.

Gestational Diabetes Linked to Birth Injury: Neonatal Jaundice

Mothers with gestational diabetes can sometimes have poor placental perfusion, which can cause chronic intrauterine hypoxia and placental insufficiency. These conditions can cause the baby to produce too many red blood cells. Babies’ livers break down these red blood cells, releasing a substance called bilirubin into the blood. When too much bilirubin is released (hyperbilirubinemia), the baby’s skin and eyes can turn yellowish in a condition called jaundice.

Jaundice is a sign that should be reported to a medical professional for immediate treatment. In some babies, jaundice goes away on its own, but in other cases, babies may need some help. When babies need help eliminating bilirubin, they are put under blue phototherapy lights. If jaundice isn’t treated properly, bilirubin can continue to accumulate to toxic levels and cross the blood-brain barrier. If bilirubin reaches the brain, it causes brain damage in a condition called kernicterus – a condition which is always avoidable.

Causes of Gestational Diabetes

Pregnancy hormones can block insulin from doing its job. A hormone called placental lactogen can interfere with susceptible insulin receptors. When this happens, glucose levels increase in the pregnant woman’s blood.

Risk Factors for Gestational Diabetes

A woman is at greater risk for gestational diabetes if she has any of the following conditions:

  • Is older than 25 years of age during pregnancy
  • A family history of type 2 diabetes
  • Gave birth to a baby that weighed more than 9 pounds or had a birth defect
  • Previous poor obstetric history
  • High blood pressure and preeclampsia
  • Too much amniotic fluid
  • An unexplained miscarriage or stillbirth
  • Overweight before pregnancy
  • Polycystic ovary syndrome
  • A previous diagnosis of gestational diabetes or prediabetes, impaired glucose tolerance, or impaired fasting glycemia

Signs and Symptoms of Gestational Diabetes

Usually there are few or no symptoms, and in most cases, gestational diabetes is diagnosed by testing for it during pregnancy (screening).

Symptoms may include:

  • Blurred vision
  • Fatigue
  • Frequent infections, including those of the bladder, vagina, and skin
  • Increased thirst
  • Increased urination
  • Nausea and vomiting
  • Weight loss despite increased appetite

Diagnosing Gestational Diabetes Through Blood Tests

The American Congress of Obstetrics and Gynecologists (ACOG) recommends that all pregnant women receive an oral glucose tolerance test between the 24th and 28th week of pregnancy to screen for gestational diabetes. Women who have risk factors for it may have this test earlier in the pregnancy, typically around the 18th week of pregnancy.

Usually, testing for gestational diabetes is done by having the pregnant woman drink a syrupy solution, with a blood test to check glucose level given an hour later. A follow-up test is then given, whereby the patient fasts overnight, and then has her blood sugar tested the next morning. After the test, she will drink a solution that has an even higher level of glucose than the syrupy solution given during the initial test. The patient’s blood glucose level will then be checked every hour for a period of three hours. If at least two of the blood glucose readings are higher than normal, the patient will be diagnosed with gestational diabetes.

Treatment for Gestational Diabetes

Once a patient is diagnosed with gestational diabetes, the physician will have her monitor her diabetes by testing her glucose level at home. The most common way involves obtaining a drop of blood from a finger and putting it on a device that will give a glucose reading. The goals of treatment are to keep blood glucose levels within normal limits during the pregnancy, and to make sure the growing baby is healthy.

With gestational diabetes, frequent check-ups by the physician are essential, especially during the last three months of pregnancy. The physician will carefully monitor the patient’s blood glucose levels. Other tests to monitor the baby’s health include:

  • Fetal monitoring to check the size and health of the fetus.
  • A nonstress test (NST), which measures the baby’s heart rate. The heart rate should increase when the baby moves. If the baby’s heart doesn’t beat faster during movement, the baby may not be getting enough oxygen.
  • A biophysical profile (BPP), which combines a nonstress test with an ultrasound study of the baby. There is a scoring system that enables the physician to evaluate the baby’s heartbeat, movements, breathing and overall muscle tone, and determine whether the baby is surrounded by a normal amount of amniotic fluid. The baby’s scores on heartbeat, breathing and movement help the physician determine if the baby is getting enough oxygen. When the amniotic fluid index (AFI) is low, it may mean that the baby hasn’t been urinating enough. This could indicate that over time, the placenta has not been working as well as it should.
  • Doppler flow studies test how well blood is flowing to the baby’s brain, organs and other parts of the body.

In addition to close monitoring, it is recommended that mothers with gestational diabetes be treated with diet, oral hypoglycemic medications or insulin.

Gestational Diabetes: Steps for a Healthy Pregnancy, Labor and Delivery

At 32 weeks of gestation, the mother should have prenatal testing done at least every two weeks. This includes a nonstress test with amniotic fluid index (AFI). An ultrasound to estimate fetal weight should be done at 36 to 39 weeks as well. If a mother with gestational diabetes has other complicating factors, such as obesity or preeclampsia, prenatal testing should be more frequent and a planned delivery may need to occur at an earlier date.

Labor Induction and Gestational Diabetes

It is common practice to induce labor prior to 40 weeks for women with gestational diabetes as a strategy to reduce complications, especially those related to macrosomia. Labor induction is often planned at 38 ½ to 39 weeks’ gestation, and can occur when the baby’s lungs are mature, antepartum tests are normal, diabetes is under control, and the mother doesn’t have vascular disease.

ACOG recommends consideration of C-section delivery in diabetic women when estimated fetal weight exceeds 4500 grams. Some researchers recommend considering C-section delivery when the estimated weight is between 4000 and 4500 grams, after evaluating obstetrical history and clinical measurements of the pelvis. Physicians should be alerted to the possibility of cephalopelvic disproportion if  dilation or descent stops during labor, and the baby’s estimated weight exceeds 4000 grams. These researchers also suggest consideration of C-section delivery in diabetic women who demonstrate significant protracted labor and failure of descent.

Physicians have to consider a number of factors when caring for a woman with gestational diabetes and her baby. Due to the variety and complexity of these issues, it is essential that medical professionals monitor and treat the mother and baby very closely throughout the pregnancy, labor, and delivery.


Legal Help for Gestational Diabetes and Birth Injury

Reiter & Walsh, P.C. | Trusted Birth Injury Attorneys

Birth Injury Attorneys | Reiter & Walsh, PC | Gestational DiabetesAll pregnant women must be screened for gestational diabetes around 28 weeks of pregnancy. If the initial glucose tolerance test indicates that an expectant mother might be diabetic, medical professionals should administer a more intensive three-hour glucose test. It is critical for a pregnant woman’s doctor to accurately read the results of gestational diabetes tests in order to prescribe the correct diet and medication.

If your doctor failed to diagnose your gestational diabetes and your baby suffered a birth injury as a result, you may have the right to collect damages in a medical malpractice lawsuit. E-mail or call Reiter & Walsh ABC Law Centers at (888) 812-6009 for a free consultation. Our Detroit, Michigan birth injury attorneys will provide you with a free case review and inform you of your legal options. We never charge until we win or settle your case, and our attorneys handle cases all over the United States, in places including Pennsylvania, Tennessee, Mississippi, Texas, Wisconsin, Michigan, Ohio, Washington D.C., Arkansas, and more. Additionally, our team handles cases involving military hospitals and federally funded clinics.

If your child was diagnosed with a birth injury from mismanaged gestational diabetes, the award-winning birth injury lawyers at ABC Law Centers can help. To begin your free case review, you may contact us in any of the following ways:

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Sources

  • Getahun D, Nath C, Ananth CV, Chavez MR, Smulian JC. Gestational diabetes in the United States: temporal trends 1989 through 2004. Am. J. Obstet. Gynecol. 198(5),525.E1-525.E5 (2008).
  • American Diabetes Association. Clinical practice recommendations 2001: gestational diabetes mellitus. Diabetes Care 24(Suppl. 1),S77-S79 (2001).
  • Maso, Gianpaolo, Salvatore Alberico, Uri Wiesenfeld, Luca Ronfani, Anna Erenbourg, Eran Hadar, Yariv Yogev, and Moshe Hod. “GINEXMAL RCT: Induction of labour versus expectant management in gestational diabetes pregnancies.” BMC pregnancy and childbirth 11, no. 1 (2011): 1-7.

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