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Recent Study Finds Benefits of ECMO during Therapeutic Hypothermia for Infants with HIE

Babies with hypoxic-ischemic encephalopathy (HIE) often experience respiratory problems. Because of this, they may require assistance with breathing after birth. This can be done through the urgent method of resuscitation, or the more long-term assistance of inhaled nitric acid, high-frequency ventilation, or extracorporeal membrane oxygenation (ECMO) (1). These long-term practices are commonly used for neonates…

Recent Findings on the Association Between Placental Lesions and HIE

Hypoxic-ischemic encephalopathy (HIE) is a brain injury caused by insufficient oxygenated blood flow to the brain at or near the time of delivery. There are many potential causes of HIE, including high-risk pregnancy conditions, labor and delivery issues, and medical mistakes. Recent studies have sought to find connections between placental and umbilical cord issues and…

Researchers identify pregnancy conditions that increase the risk of neonatal hypoxia

Hypoxic-ischemic encephalopathy (HIE), a type of newborn brain damage caused by oxygen deprivation during or around the time of birth, has been linked to a variety of pregnancy conditions. Inna Skarga-Bandurova and colleagues in the Ukraine recently published a study on risk factors for chronic fetal hypoxia (i.e. long-term oxygen deprivation). They analyzed data from…

New study finds neuroprotective benefits in resveratrol (RESV)

Recent studies in rats indicate that resveratrol (RESV), a natural polyphenol compound, may be useful in minimizing brain damage from hypoxic-ischemic encephalopathy (HIE). Studies of resveratrol’s neurological benefits This study, published in November, showed the surprising neuroprotective benefits of resveratrol (1). In the study, 48 seven-day-old rats were broken up into four groups, all of…

New VaPor Model Provides More Details About the Effects of Therapeutic Hypothermia for HIE

What Is Therapeutic Hypothermia? Therapeutic hypothermia has proven effectiveness in minimizing permanent brain damage after hypoxic-ischemic encephalopathy, or HIE. HIE is a type of brain injury caused by a lack of oxygenated blood flow. In infants, it can occur due to complications in late pregnancy, birth, or the neonatal period. What Do We Already Know…

New Treatment for Cerebral Palsy: M2 Macrophage Transplantation Improves Motor and Cognitive Function

Cell transplantation is a promising new avenue for treating cerebral palsy (CP). Previous research has shown that stem cell therapy can help children with cerebral palsy; a study published this month indicates that treatment with macrophages may also be effective.  Essentially, macrophages are cells that can repair damaged brain tissue and blood vessels, thereby enhancing…

Improving Neurological Outcomes of HIE: Monosialoganglioside Treatment

Thus far, the most effective medical intervention for infants with hypoxic-ischemic encephalopathy (HIE) is hypothermia therapy, or cooling treatment. When administered very shortly after birth or the oxygen-depriving incident, this therapy can reverse brain damage and minimize (or in some cases prevent) permanent harm. However, hypothermia therapy is not always effective, and additional solutions for…

Antenatal Magnesium Sulfate Prevents Cerebral Palsy in Preterm Infants

Premature babies have lower survival rates than full-term infants, and those that survive have an increased chance of developing lifelong disabilities such as cerebral palsy. During the birthing process, their fragile bodies are highly susceptible to hypoxic-ischemic encephalopathy (brain damage caused by oxygen deprivation) and other injuries. Even if they make it through the birthing…