Hypoxic-ischemic encephalopathy (HIE), a type of newborn brain damage caused by oxygen deprivation during or around the time of birth, has been linked to a variety of pregnancy conditions. Inna Skarga-Bandurova and colleagues in the Ukraine recently published a study on risk factors for chronic fetal hypoxia (i.e. long-term oxygen deprivation). They analyzed data from…
Recent studies in rats indicate that resveratrol (RESV), a natural polyphenol compound, may be useful in minimizing brain damage from hypoxic-ischemic encephalopathy (HIE). Studies of resveratrol’s neurological benefits This study, published in November, showed the surprising neuroprotective benefits of resveratrol (1). In the study, 48 seven-day-old rats were broken up into four groups, all of…
Hypothermia therapy, or brain cooling, is the standard treatment for hypoxic-ischemic encephalopathy (HIE). It can reduce the extent of permanent brain damage if given very shortly after birth or the oxygen-depriving incident (within six hours, though there may be some benefit from the therapy up to 24 hours). Using a cooling cap or blanket, the…
What Is Therapeutic Hypothermia? Therapeutic hypothermia has proven effectiveness in minimizing permanent brain damage after hypoxic-ischemic encephalopathy, or HIE. HIE is a type of brain injury caused by a lack of oxygenated blood flow. In infants, it can occur due to complications in late pregnancy, birth, or the neonatal period. What Do We Already Know…
Hypoxic-ischemic encephalopathy (HIE) is a type of birth injury that occurs when an baby’s brain is deprived of oxygenated blood at or around the time of birth. HIE is a major cause of neurological damage in term and near-term infants, and accounts for about 25% of deaths during the neonatal period. Even short durations of…
Cell transplantation is a promising new avenue for treating cerebral palsy (CP). Previous research has shown that stem cell therapy can help children with cerebral palsy; a study published this month indicates that treatment with macrophages may also be effective. Essentially, macrophages are cells that can repair damaged brain tissue and blood vessels, thereby enhancing…
Thus far, the most effective medical intervention for infants with hypoxic-ischemic encephalopathy (HIE) is hypothermia therapy, or cooling treatment. When administered very shortly after birth or the oxygen-depriving incident, this therapy can reverse brain damage and minimize (or in some cases prevent) permanent harm. However, hypothermia therapy is not always effective, and additional solutions for…
Premature babies have lower survival rates than full-term infants, and those that survive have an increased chance of developing lifelong disabilities such as cerebral palsy. During the birthing process, their fragile bodies are highly susceptible to hypoxic-ischemic encephalopathy (brain damage caused by oxygen deprivation) and other injuries. Even if they make it through the birthing…
Currently, the only available treatment for hypoxic-ischemic encephalopathy (HIE), besides supportive care and therapy to mitigate the symptoms, is hypothermia therapy. This involves cooling a baby down to a below-normal temperature in order to allow the brain to recover from a hypoxic-ischemic injury and limit the spread of damage. Hypothermia therapy is known to reduce…
We are excited to introduce a new regular column: Disability Non-Profit of the Month. There are many fantastic non-profits serving those with disabilities, and these organizations often do not get the recognition they deserve. Moreover, the people who could benefit most from their services may not even know they exist. We hope that this series…
