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Recent Findings on the Association Between Placental Lesions and HIE

Hypoxic-ischemic encephalopathy (HIE) is a brain injury caused by insufficient oxygenated blood flow to the brain at or near the time of delivery. There are many potential causes of HIE, including high-risk pregnancy conditions, labor and delivery issues, and medical mistakes. Recent studies have sought to find connections between placental and umbilical cord issues and…

Researchers identify pregnancy conditions that increase the risk of neonatal hypoxia

Hypoxic-ischemic encephalopathy (HIE), a type of newborn brain damage caused by oxygen deprivation during or around the time of birth, has been linked to a variety of pregnancy conditions. Inna Skarga-Bandurova and colleagues in the Ukraine recently published a study on risk factors for chronic fetal hypoxia (i.e. long-term oxygen deprivation). They analyzed data from…

New study finds neuroprotective benefits in resveratrol (RESV)

Recent studies in rats indicate that resveratrol (RESV), a natural polyphenol compound, may be useful in minimizing brain damage from hypoxic-ischemic encephalopathy (HIE). Studies of resveratrol’s neurological benefits This study, published in November, showed the surprising neuroprotective benefits of resveratrol (1). In the study, 48 seven-day-old rats were broken up into four groups, all of…

Large Head Circumference At Birth Increases Risk of White Matter Damage and Cerebral Palsy

One of the major risk factors for cerebral palsy (CP) is damage to the brain’s white matter. In preterm infants, white matter damage often stems from asphyxia (oxygen deprivation), but in term infants the cause of damage may occasionally be difficult to determine. However, new research by Arne Jensen and Bert Holmer, published in Obstetrics…

Cerebral Palsy: Environmental and Genetic Factors

Cerebral palsy is a diagnosis that varies in type and severity of neurodevelopmental outcomes. People with cerebral palsy have impaired motor function, and in some cases also have cognitive disabilities. Cerebral palsy can be caused by environmental and/or genetic factors. Environmental Causes of Cerebral Palsy Cerebral palsy can often be attributed to something that goes…

Hypothermia Therapy May Be Effective 6-24 Hours After Birth

Currently, the only available treatment for hypoxic-ischemic encephalopathy (HIE), besides supportive care and therapy to mitigate the symptoms, is hypothermia therapy. This involves cooling a baby down to a below-normal temperature in order to allow the brain to recover from a hypoxic-ischemic injury and limit the spread of damage. Hypothermia therapy is known to reduce…

Hypothermia Therapy Shortly After Birth Reduces Risk of Epilepsy

Babies that have sustained oxygen-depriving injuries (perinatal asphyxia) during the birthing process can benefit greatly from prompt administration of hypothermia therapy. Cooling an injured newborn to a below-normal temperature can give brain cells a chance to repair themselves, which stops the damage from spreading and becoming permanent. Hypothermia therapy can prevent or decrease the severity…

Combination EPO and Hypothermia Therapy in Babies with HIE | Birth Injury Research Update

A new research paper released in Pediatrics examines the impact of administering high-dose erythropoietin (EPO) in conjunction with hypothermia therapy (brain cooling) for babies with hypoxic-ischemic encephalopathy (HIE). The paper describes the result of Phase II clinical trials. Background: Hypothermia Therapy as the Standard of Care for Treating HIE The standard of care for babies…