Hypothermia therapy, or brain cooling, is the standard treatment for hypoxic-ischemic encephalopathy (HIE). It can reduce the extent of permanent brain damage if given very shortly after birth or the oxygen-depriving incident (within six hours, though there may be some benefit from the therapy up to 24 hours). Using a cooling cap or blanket, the…
Hypoxic-ischemic encephalopathy (HIE) is a type of birth injury that occurs when an baby’s brain is deprived of oxygenated blood at or around the time of birth. HIE is a major cause of neurological damage in term and near-term infants, and accounts for about 25% of deaths during the neonatal period. Even short durations of…
One of the major risk factors for cerebral palsy (CP) is damage to the brain’s white matter. In preterm infants, white matter damage often stems from asphyxia (oxygen deprivation), but in term infants the cause of damage may occasionally be difficult to determine. However, new research by Arne Jensen and Bert Holmer, published in Obstetrics…
Cerebral palsy is a diagnosis that varies in type and severity of neurodevelopmental outcomes. People with cerebral palsy have impaired motor function, and in some cases also have cognitive disabilities. Cerebral palsy can be caused by environmental and/or genetic factors. Environmental Causes of Cerebral Palsy Cerebral palsy can often be attributed to something that goes…
Currently, the only available treatment for hypoxic-ischemic encephalopathy (HIE), besides supportive care and therapy to mitigate the symptoms, is hypothermia therapy. This involves cooling a baby down to a below-normal temperature in order to allow the brain to recover from a hypoxic-ischemic injury and limit the spread of damage. Hypothermia therapy is known to reduce…
Babies that have sustained oxygen-depriving injuries (perinatal asphyxia) during the birthing process can benefit greatly from prompt administration of hypothermia therapy. Cooling an injured newborn to a below-normal temperature can give brain cells a chance to repair themselves, which stops the damage from spreading and becoming permanent. Hypothermia therapy can prevent or decrease the severity…
A new research paper released in Pediatrics examines the impact of administering high-dose erythropoietin (EPO) in conjunction with hypothermia therapy (brain cooling) for babies with hypoxic-ischemic encephalopathy (HIE). The paper describes the result of Phase II clinical trials. Background: Hypothermia Therapy as the Standard of Care for Treating HIE The standard of care for babies…
Brain research is an ongoing process, and, at the moment, hypothermia therapy (using a cooling cap, cooling pad, or cooling blanket) is the standard of care when it comes to hypoxic ischemic encephalopathy. Additive or supplemental measures in addition to hypothermia are still in preclinical or clinical trials, so it is too early to say…
Brain Awareness Week is March 14-20, 2016! The human brain is a complex system. While medical research is making great strides in understanding the biochemistry and biology underlying brain function, there is still a long way to go. Because of the delicate nature of the brain and its role in cognition and human health, the…
According to the Journal of Patient Safety, preventable medical errors cause at least 210,000 deaths per year. Medical errors are the third leading cause of death in America, behind heart disease and cancer. Unfortunately, mistakes made in the Neonatal Intensive Care Unit (NICU) represent a significant part of those numbers. The Archives of Disease in…
