Research on Sildenafil (Viagra) and Fetal Distress Halted

/0 Comments/in /by

Sildenafil citrate is the phosphodiesterase-V inhibitor more commonly known as the erectile dysfunction drug, Viagra (1). A recent trial study of sildenafil was performed by Saleish Kumar of the Mater Research Institute at the University of Queensland, Australia. The aim of the study was to reduce the instance of fetal distress during labor. Fetal distress…

Clinical Trial of Cannabidiol (CBD) in Newborns with Hypoxic-Ischemic Encephalopathy

/0 Comments/in /by

Hypoxic-ischemic encephalopathy (HIE) is a type of brain damage caused by a disruption in the flow of oxygenated blood to the brain. One of the main populations that it affects is newborns who have experienced birth asphyxia (oxygen deprivation during or near the time of birth) (1).  Currently, the most effective treatment for HIE is…

Recent Study Finds Benefits of ECMO during Therapeutic Hypothermia for Infants with HIE

/in , /by

Babies with hypoxic-ischemic encephalopathy (HIE) often experience respiratory problems. Because of this, they may require assistance with breathing after birth. This can be done through the urgent method of resuscitation, or the more long-term assistance of inhaled nitric acid, high-frequency ventilation, or extracorporeal membrane oxygenation (ECMO) (1). These long-term practices are commonly used for neonates…

Recent Findings on the Association Between Placental Lesions and HIE

/in /by

Hypoxic-ischemic encephalopathy (HIE) is a brain injury caused by insufficient oxygenated blood flow to the brain at or near the time of delivery. There are many potential causes of HIE, including high-risk pregnancy conditions, labor and delivery issues, and medical mistakes. Recent studies have sought to find connections between placental and umbilical cord issues and…

New study finds neuroprotective benefits in resveratrol (RESV)

/0 Comments/in /by

Recent studies in rats indicate that resveratrol (RESV), a natural polyphenol compound, may be useful in minimizing brain damage from hypoxic-ischemic encephalopathy (HIE). Studies of resveratrol’s neurological benefits This study, published in November, showed the surprising neuroprotective benefits of resveratrol (1). In the study, 48 seven-day-old rats were broken up into four groups, all of…

New studies on Sildenafil treatment in babies with hypoxic-ischemic encephalopathy (HIE)

/0 Comments/in /by

Sildenafil is the phosphodiesterase-V inhibitor more commonly known as Viagra (1). It has been successful in treating pediatric pulmonary arterial hypertension (PAH) because it increases blood pressure in the lungs. It has grown in usage and is now the major treatment option for PAH in babies, even though it is still used off-label and requires…

Piglets with Hypoxic-Ischemic Brain Damage Benefit from Cannabidiol and Therapeutic Hypothermia

/in /by

Cannabidiol (CBD) is a component of the cannabis (marijuana) plant that serves a wide variety of medicinal purposes (the legality of CBD and other cannabis products varies by state). Importantly, cannabidiol has been shown to provide neuroprotection in animal models of hypoxic-ischemic encephalopathy (HIE). HIE is a type of brain injury from oxygen deprivation. In…

Autonomic Function in Babies with Hypoxic-Ischemic Encephalopathy (HIE)

/in /by

Hypoxic-ischemic encephalopathy (HIE) is a type of birth injury stemming from oxygen deprivation during or around the time of birth. Babies with HIE have brain damage which often results in permanent health conditions and disabilities such as cerebral palsy. Although brain imaging and other diagnostic techniques can help medical professionals estimate the extent of damage,…