Periventricular leukomalacia (PVL) is a serious type of neonatal brain injury that occurs when a lack of oxygen and blood flow to the brain softens and kills the brain’s white matter near the lateral ventricles, which provide pathways for cerebrospinal fluid. Fluid-filled cysts are often left in place of the dead white matter. PVL is often caused by HIE or birth trauma and can lead to cerebral palsy, epilepsy, intellectual and developmental delays (I/DD) and visual impairment. Learn how to pronounce periventricular leukomalacia here.
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